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Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists

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RSC Adv., 2013, Advance Article
DOI: 10.1039/C3RA41985A, Paper
Christelle Doebelin, Patrick Wagner, Isabelle Bertin, Frederic Simonin, Martine Schmitt, Frederic Bihel, Jean-Jacques Bourguignon
Herein is disclosed the different synthesis of derivatives devoid of any cyano group, through the use of sequential and regioselective palladium-catalyzed cross-coupling reactions starting from a trihalopyridine.
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