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Solvent-controlled, regio-switchable formation of 3-/5-arylaminopyrazole isomer in cyclocondensation of [small beta]-aminoenones with hydrazides: intermolecular hydrogen bonding plays a role

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RSC Adv., 2013, 3,386-389
DOI: 10.1039/C2RA22647B, Communication
Dexuan Xiang, Xihe Bi, Peiqiu Liao, Guichun Fang, Zikun Wang, Xiaoqing Xin, Dewen Dong
Solvent-controlled, regio-switchable Knorr-type reaction synthesizes pyrazoles in cyclocondensation of [small beta]-aminoenones with hydrazides. The reaction solvent is changed to obtain single regioisomer 3- or 5-arylaminopyrazoles.
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