Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

RSC Adv., 2013, Advance Article
DOI: 10.1039/C3RA42887G, Communication

Hu Chen, Xunfu Xu, Liu Liu, Guo Tang, Yufen Zhao
A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl₃ and DMAP.
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