Diversity-Oriented Synthesis of Spiro-Oxindole-based 2,5-Dihydropyrroles via Three-Component Cycloadditions and Evaluation on Their Cytotoxicity

, 2013, Accepted Manuscript
DOI: 10.1039/C3RA40874D, Paper

Wei Tan, Xiao-Tong Zhu, Shu Zhang, Gui-Juan Xing, Ren-Yi Zhu, Feng Shi
The construction of spiro-oxindole-based 2,5-dihydropyrrole scaffold with potential bioactivity has been established via an efficient three-component reaction of isatin, amino-ester and alkyne. This protocol represents the first 1,3-dipolar cycloaddition of...
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